The Pathways goal is to develop a better understanding of how to implement and scale up interventions and programs that will address Aboriginal health inequities in four priority areas -- suicide, obesity, tuberculosis, and oral health for Aboriginal peoples in Canada. Additional examples will be included that discuss progress and challenges in addressing health inequities faced by indigenous peoples in the United States. Health inequities and poor health status of Aboriginal peoples in both countries persist despite impressive overall gains experienced by non-Aboriginal people over the last century. Examples include the following: the prevalence of dental decay among First Nations and Inuit children aged 3–5 years is greater than 85 percent; the new case incidence of tuberculosis is 30–150 times the rate for the Canadian-born non-Aboriginal population; 36 percent of on-reserve First Nations adults are estimated to be obese and, among children, rates vary from 17 percent among Métis to 20 percent among off-reserve Aboriginal peoples; and the suicide rate for Inuit living in Northern Canada is 11 times greater than that for the general population. This symposium will present the Pathways to Health Equity for Aboriginal Peoples Initiative. It will also discuss how to implement and scale up health research in ways that are accessible with equitable interventions and programs that will address Aboriginal health inequities. The symposium will conclude by sharing leading-edge research in the field and highlight the importance of national and international collaborations.