Neuroimaging Discoveries of Protein and Circuit Convergence in Aging and Disease

Science is faced with solving the mysteries of how alterations in brain function in aging are related to protein disruption that occurs in normal aging and Alzheimer’s disease. Advanced neuroimaging now provides ways to visualize these proteins in living people. New relationships between specific protein accumulation and neural function are being revealed, with evidence for both disruption and circuit reorganization that underlie the brain’s effort to compensate in the face of aging and disease.