Deciphering the Circuit Codes for Aging and Brain Disease

The hippocampal formation is a structure in the brain that is targeted by a range of disorders that emerge across the life span, including schizophrenia and Alzheimer’s disease. Innovative neuroimaging techniques have pinpointed regions of hippocampal circuit targeted specifically by different disorders. Pinpointing circuit dysfunction is providing clues into mechanisms of disease, opening up avenues of novel interventions.