As science and engineering rapidly advance and more often span a global Science, Technology, and Innovation (STI) community, how can the U.S. strengthen its ability to look to the horizon and translate that vision into research and action for scientists, institutions, industry, and government? Looking to the horizon implies at least three different activities: looking up from a focused, discipline- or institution-based view; looking out to see what other countries are doing, especially in terms of potential STI collaboration; and looking ahead to understand trends being driven by transformational technologies at the STI frontier. The U.S. bottom-up, discipline-based system of research and development, coupled with a can-do, merit-based approach has long yielded unrivaled creativity and innovation. The excellence and size of the U.S. scientific and industrial communities meant that its scientists and institutions rarely looked outside the U.S. and rarely faced strong international competition for new ideas, infrastructure, or funding. Given the emergence of high-impact interdisciplinary fields and recent large STI investments by many nations, how can we complement and fortify the U.S. bottom-up structure within and across universities, industry, and government, and increase the ability to gather, analyze, synthesize, and share institutional, national, and global STI information? This session includes academic, industry, and government leaders at the forefront of understanding the global STI landscape.