Computer and video games have emerged as one of the most powerful media of the 21st century, generating billions of hours of highly engaging entertainment. A growing body of research is also highlighting the enormous potential of games and game-infused experiences to help address some of the most pressing social, cultural, scientific, and economic challenges of the 21st century. To take advantage of this power to captivate, we need to create therapeutic and educational video games that are as much fun and as appealing as the most popular commercial games. As President Obama told a college audience, “I want you guys to be stuck on a video game that’s teaching you something other than just blowing something up.” Unfortunately, a significant gap remains between the growing body of research highlighting the potential for game-based learning and the transformation of these findings into scalable products and services. This symposium discusses how to understand and bridge this gap.