The symposium proposes a new global partnership between funders of health research to promote international cooperation on poverty-related diseases between researchers from the “South” and those from the “North.” Poverty-related diseases affect the world’s poorest and most marginalized communities. They undermine productivity and increase insecurity and infirmity, thus perpetuating the cycle of poverty. While general improvements of nutrition, sanitation, and health infrastructures will be important, an effective long-term control will also require the development of improved medical interventions. However, there is a general lack of both public and private investments. The formation of international and cross-sectorial partnerships between research performers and funders, from both the public and private sector, has proven to be a viable and effective way for accelerating the development of improved medical interventions. Pioneering international partnerships, such as the European and Developing Countries Clinical Trials Partnership, succeeded in bridging the strategic, financial, and cultural boundaries and generating results which would not have been achieved by single countries and single sectors acting alone. The symposium focuses on innovative ideas in bringing on new partners, increasing engagement of public funders, and leveraging private funding from different sectors. The panel will present and discuss new financing and partnership mechanisms.