It is well know that nucleic acid base-pairing is the basis of information transfer in living systems. In addition, nucleic acid base-pairing provides a remarkable tool for designing and engineering complex nucleic acid structures and circuits. Over the past several years, work in the field of nucleic acid nanotechnology has accelerated to the point that intricate three-dimensional (3D) nucleic acid nanostructures can be constructed either by folding with precision staples (origami) or by self-assembly of the staples themselves, in an act reminiscent of a house constructing itself from its own wooden pieces. In addition, macroscopic 3D crystals can be self-assembled, and information-containing DNA nanoconstructs can be self-replicated. In parallel, nucleic acids have been adapted to computation, with circuits generated that can amplify signals, take square roots, and even act as neural networks. This symposium will consist of talks by some of the luminaries in this field, highlighting the remarkable intellectual arc that led from the first conception of engineered structures in the 1980s to the construction of nucleic acid robots and assembly lines today, the design and construction of nucleic acid nanostructures, and nucleic acid circuits and their applications. Because DNA is both biocompatible and biodegradable, these technologies are highly suitable for medical applications.