Self-Assembled DNA Nanostructure Tools for Molecular Biophysics

Using DNA strands to construct particles with precisely specified shapes, we are able to approximate a level of complexity that rivals that of the molecular machinery found in cells. We are also pioneering methods for hierarchical assembly of these particles into 3D networks, with site-specific control over chemical functionalization and mechanical actuation. Because DNA is both biocompatible and biodegradable, these programmable nanodevices are highly suitable for medical applications.