DNA Cages and Nanotubes: Simple, DNA‑Minimal Synthesis and Biological Properties

3D DNA nanostructures have the potential to deliver drugs, regulate proteins, and assemble networks. We have built DNA structures that can be dynamically switched to different internal volumes, opened or closed on-demand, and triggered to release encapsulated cargo. Moreover, these compact structures can travel across the plasma membrane of a number of mammalian cells without the aid of transfection reagents, representing a new class of selective cellular probes and drug delivery tools.