American children underperform many counterparts in the developed world on international metrics of educational competence. Among American children, individuals from low-income households and families of color or with English-language challenges underperform others at school entry. Gaps in school readiness and early performance have proven difficult to overcome, lacking cumulative interventions and sustainable outcomes. The School Reform and Beyond Project (SRB), a 10-year collaboration joining researchers from several institutions with practitioners, addresses these challenges by drawing from and innovating at the intersection of the developmental and intervention sciences. The ultimate goal of SRB is to take to national scale a sustainable, efficient, and developmentally integrated set of evidence-based interventions that accelerate learning of all children from birth onward. The integrated interventions of SRB include the following: elevating school readiness by supporting and resourcing parents to more effectively prepare infants and toddlers from birth for healthy, successful entry to pre-K; and maximizing the start to schooling -- pre-K through grade 5 -- by integrating the best evidence-based strategies for promoting academic proficiency with strategies to promote social and emotional development and self-regulated learning. The symposium presents the rationale, design, and early testing of the SRB model of integrated interventions.