Since the publication of the Fourth Intergovernmental Panel on Climate Change (IPCC) Assessment Report in 2007, national and international security organizations increasingly recognize global warming as a threat to national and regional security. Concerns center on forecasts of climate-related natural disasters such as flooding, cyclones, and drought and their impacts on food, fresh water, and infrastructure. Such events and their consequent impacts on human disease and migration could pose significant stresses on vulnerable nations in coming years. Sound planning to adapt and respond to the challenges of climate change will depend on sound science to characterize the threat and to evaluate alternative approaches and on effective knowledge exchange across research and security communities. Bangladesh will be at the forefront of global response to climate change given its vulnerability to the impacts. Bangladeshi scientists at home and abroad serve as lead authors on the Fifth IPCC Assessment Report. The Ministry of Environment and Forests is the lead agency for the national adaptation program. Nongovernmental organizations (NGOs) often serve as knowledge brokers between research and policy communities. This symposium examines the ways that cross-sectoral and international collaboration must work to apply sound science to develop sound policies and programs for adaptation to climate change, using Bangladesh as its case for study.