Bragg's Law has given us vital insights into everything, from the human immunodeficiency virus (HIV) to the ribosome that produces the thousands of proteins that make our bodies work. In 1912, M. von Laue recorded the first X-ray diffraction pattern. His data caught the eye of L. Bragg who, along with his father, set about reinterpreting the pictures published by von Laue’s group. This led to Bragg’s Law, which provided a powerful new tool for working out crystal structures using X-ray diffraction -- a vital technique that has already led to the understanding of how genes copy themselves, winning Professor Kornberg the Nobel Prize in Chemistry in 2006 and the 2009 Nobel Prize for work that revealed the structure of the ribosome. This symposium will take the audience on a journey, looking at the impact of Bragg’s Law and advances in X-ray science over the past century, while focusing on the latest breakthroughs in the biomedical field, where diffraction is used to unravel the dangerously beautiful structures of HIV and the hand, foot, and mouth virus and provide valuable information on life-threatening heart diseases.