Brain Function and Plasticity A series of innovative studies are being done to map the brain from the molecular to the systems level both structurally and functionally. At the synaptic level, how neurotransmitters, their receptors, and signaling pathways influence neural function and plasticity is becoming much better understood. Integrating neuronal function at the level of single neurons and groups of neurons into larger circuits at the anatomical level in the mammalian brain, while a daunting task, is being studied by advanced imaging techniques requiring vast amounts of information storage and processing. To integrate local circuit function with whole brain function, understanding the structure and processing of brain networks is critical. A major project to accomplish this task, the Human Connectome Project, is in the process of integrating the structure and function of brain networks using the most advanced imaging and analysis techniques in 1,200 people, including twins and their nontwin siblings. This step will allow for major new insights into not only brain structure and function, but also their genetic underpinnings. Comparing this information in both the normal brain and in different brain disorders such as neurodegenerative diseases is providing novel insights into how understanding brain function from the molecular to the systems level will provide insights into normal brain function and disease pathogenesis as well as provide new treatment strategies.