Molecules and Mechanisms Involved in Synaptic Plasticity in Health and Disease

Conditions required to induce types of synaptic plasticity in the brain termed long-term synaptic potentiation (LTP) or depression (LTD) vary depending on the history of cellular or synaptic activity, a property now called metaplasticity. The molecular mechanisms of bidirectional synaptic plasticity and metaplasticity will be discussed in the context of normal neural mechanisms and in disease.