Regenerating Human Oral Mucosa

This presentation will discuss the strategy for regenerating human oral mucosa for soft tissue engineering in craniomaxillofacial surgery. We will illustrate this by (1)  showing how we fabricate, under cGMP standards consistent with the regulatory guideline of the FDA, a human tissue engineered oral mucosa suitable for intraoral grafting, (2) show results from our completed Phase I clinical trial, (3) discuss preliminary data on our recently funded Phase II and I/II clinical trials and (4) present preliminary data on the manufacture of muco-cutaneous constructs that will be used to form a set of human lips for facial reconstruction.as well as for use in fabricating a neoanus.