One Health has emerged as a multidisciplinary effort to attain optimal health of humans, animals, and our environment. Emerging zoonotic diseases, food- and water-borne diseases, and environmental change pose increasing threats to health on a global basis. The One Health vision is being embraced institutionally while being practiced locally. Participants will focus on implementing One Health principles through both public health policy support and concrete actions at the human-animal-environment interface. This session will provide updates on the status of large international initiatives related to One Health, ongoing policy-related working groups based on interdisciplinary international collaborations, and specific presentations that describe One Health being practiced at the local level, including efforts in developing countries.