Effectively conceptualizing and addressing core 21st century issues requires integrating approaches across the intellectual and technical continuums occupied by the sciences and the humanities. Anthropology is the most humanistic of the sciences and the most scientific of the humanities. Our history and place in the world as simultaneous biological and cultural beings and the ways in which we conceive of and exploit our surroundings are core facets of any dynamic systems approach to 21st century global crisis and solutions. For nearly a century, anthropology has tackled global issues of humanity by deploying an interdisciplinary tool kit to create and disseminate knowledge that cuts across boundaries. Anthropological knowledge spans millennia and embraces the full range of diversity in the physical form and cultural expression encompassing the human experience. In this session, panelists will show that anthropology as an integrative humanistic and a scientific approach creates important and flattening effects on global knowledge and understanding humanity. Speakers will integrate human evolution and our material past, contextualize social norms and practices, explore integrative methodologies and their process, and specifically examine core topics in race, health, the environment, and our interface with other creatures on this planet.