Recent scientific and technological developments and innovations have significantly improved the quality of life and saved lives in the developed world. But, these developments are not introduced to the developing and underdeveloped countries. We still face unprecedented health-care challenges in the 21st century. The prevalence of major diseases today, from the global AIDS pandemic to antibiotic-resistant tuberculosis, cuts across the health-care, political, economic, social, and biomedical disciplines. These diseases will continue to affect the world unless major measures are taken to develop comprehensive prevention and treatment programs. Thus, engineers and scientists are expected to play a critical role in developing novel and affordable health-care technology and medications to solve global health-care problems, especially in the developing and underdeveloped countries. The objectives of this special symposium are to discuss the global health-care systems, financing, delivery, and management.