Interfering with Gene Expression and Interfering with Disease

Monday, February 21, 2011: 9:45 AM-12:45 PM
147A (Washington Convention Center )
This symposium will discuss the basic biology of gene regulation by endogenous small RNAs, called microRNAs, which regulate a cell's response to developmental and environmental cues. Each microRNA regulates the expression of hundreds and possibly thousands of genes that bear partially complementary sequences, mostly in the 3'-untranslated region of the messenger RNA. This symposium will discuss microRNAs that regulate cell division, differentiation, survival, and immune responses. New methods to identify microRNA-regulated genes will be described. This symposium will also discuss how the RNA interference machinery, which is present in all cells, can be harnessed to inhibit disease-causing genes for therapy.
Judy Lieberman, Harvard Medical School
Robert Darnell, Rockefeller University
Identifying microRNA-Regulated Genes
Paloma Giangrande, University of Iowa Health Care
Aptamer-siRNA Chimeras for Targeting Prostate Cancer
Judy Lieberman, Harvard Medical School
Interfering with Sexually Transmitted Infection
John Maraganore, Alnylam Pharmaceuticals
Interfering with Disease
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