A committee formed by the Association of American Medical Colleges and the Howard Hughes Medical Institute recently examined the natural science competencies for entering medical students and those that a graduating physician needs to practice science-based medicine effectively with the goal of achieving greater synergy and efficiency in the continuum of premedical and medical education. “Scientific Foundations for Future Physicians” concludes that a competency as opposed to a course-based approach will provide greater flexibility in the premedical curriculum and would permit undergraduate institutions to develop more interdisciplinary and integrative science courses. This session will highlight the panel's findings as well as identify opportunities and challenges in implementing the report’s recommendations.