China, Korea, and Japan — three of the world’s major scientific and technological powers — are each seeking to focus their national government support of research, development, and STEM human resources activities to address shared global challenges. They include economic recovery and performance, climate change, and safe and secure food supplies to meet the needs of growing populations. In this symposium, China introduces potential strategies and policies that will boost the country’s innovation, particularly, the policies for promoting regional development of innovative cities and the policies to stimulate sustainable and innovative development of a Chinese economy in economic crises. Korea is introducing a new paradigm for national development to overcome the global economic crisis with sustainable development and job creation. It includes a vision and goals for green research and development (R&D) policy, an investment direction for green technology R&D, and a green technology development strategy and future path. Japan will introduce an evaluation of its current national S&T and innovation policy and analyze policy tools including human resource development and collaboration between companies and universities. Finally, it proposes a future framework to bridge a gap between knowledge and global issues.