Translational and Personalized Medicine This seminar will address the rapidly moving scientific and technological field of genomics and its utility in elucidating the biological basis of human diseases and developing molecular diagnostics that can be used to individualize drug therapy of human diseases. Lectures will cover the first successful whole genome sequencing of a human cancer and the potential of this strategy to reveal genomic determinants of human cancers and to identify potential novel targets for developing new anticancer agents; and pharmacogenomics and how this field is changing the drug discovery paradigm and the way medications are "personalized" based on each patient's genome. Topics include whole-genome sequencing using "next-generation" technologies, genome-wide single-nucleotide polymorphism (SNP) analyses (> 1 MM SNPs) and candidate gene strategies, and ultimately the computational, ethical, and privacy issues surrounding the generation of whole genome data for individual patients. This field of science and technology will touch every area of health care in the coming decade.