Genome Analyses and Sequencing To Advance Drug Discovery and Treatment

Translational and Personalized Medicine
Friday, February 19, 2010: 1:30 PM-3:00 PM
Room 17B (San Diego Convention Center)
This seminar will address the rapidly moving scientific and technological field of genomics and its utility in elucidating the biological basis of human diseases and developing molecular diagnostics that can be used to individualize drug therapy of human diseases. Lectures will cover the first successful whole genome sequencing of a human cancer and the potential of this strategy to reveal genomic determinants of human cancers and to identify potential novel targets for developing new anticancer agents; and pharmacogenomics and how this field is changing the drug discovery paradigm and the way medications are "personalized" based on each patient's genome. Topics include whole-genome sequencing using "next-generation" technologies, genome-wide single-nucleotide polymorphism (SNP) analyses (> 1 MM SNPs) and candidate gene strategies, and ultimately the computational, ethical, and privacy issues surrounding the generation of whole genome data for individual patients. This field of science and technology will touch every area of health care in the coming decade.
William Evans, St. Jude Children's Research Hospital
Scott Weiss, Harvard Medical School
and William Evans, St. Jude Children's Research Hospital
Richard Wilson, Washington University School of Medicine
Sequencing Cancer Genomes To Elucidate Disease Pathogenesis and Discover Drug Target
Dan Roden, Vanderbilt University School of Medicine
Challenges and Opportunities in the Assembly of Population Pharmacogenomics