Remote Regulation of Neural Activity
The system for non-invasive cell regulation uses alternating or static magnetic fields to control targeted cells, which express modified multimodal ion channels and a ferritin fusion protein to generate intracellular nanoparticles. We have validated these tools in vitro using imaging and electrophysiology to demonstrate rapid, controllable neural activation and inhibition. We have used these tools in vivo to modulating defined hypothalamic neurons. Modulating these neurons alters blood glucose and peripheral hormones and controls feeding. These studies demonstrate these technologies can be used for rapid, remote neuromodulation without the need for an implant.