Hippocampal Engrams and Time

Dr. Silva discovered how temporally related events are encoded in overlapping engrams in the hippocampus and he will discuss the neural mechanisms that integrate and link memories across time. Interestingly, this group also showed that this mechanism is disrupted in older mice, and that artificially manipulating neuronal excitability with a chemo-genetically strategy can rescue these deficits, a result that implicates this mechanism in memory linking and in age-related cognitive decline.