Hippocampal Engrams and Time

Saturday, February 18, 2017: 3:00 PM-4:30 PM
Room 311 (Hynes Convention Center)
Alcino Silva,University of California, Los Angeles, Los Angeles, CA
Dr. Silva discovered how temporally related events are encoded in overlapping engrams in the hippocampus and he will discuss the neural mechanisms that integrate and link memories across time. Interestingly, this group also showed that this mechanism is disrupted in older mice, and that artificially manipulating neuronal excitability with a chemo-genetically strategy can rescue these deficits, a result that implicates this mechanism in memory linking and in age-related cognitive decline.