A Novel Spiral Microfluidic Device for Urinalysis
This device was designed based on the principle of inertial separation using a spiral microchannel that led to particle separation based on their difference in mass, size, and inertial property. Particles in urine vary in size and mass. The device was fabricated using soft lithography technology and tested using human urine samples. The urine particles traveled through the spiral microchannel and were separated based on varying inertial characteristics into the corresponding tangent branches. A mathematic model of this separation method involving the formation of dean vortices was established. Using this device, several types of urine particles were successfully sorted and separated, followed by particle morphology study under a microscope. Separation efficiency was determined. The experiments showed that the inertial separation technique using the spiral microchannel is more effective than the other leading separation methods such as microfiltering.