Translating Epigenetics to Cellular Function and Health Outcomes

Polycyclic aromatic hydrocarbons (PAHs) are toxic compounds that form during incomplete combustion of diesel fuel, coal, wood or tobacco, and their inhalation is associated with increased severity of asthma and allergies. Our recent studies demonstrate how ambient PAHs mediate immune dysfunction through epigenetic modifications of immune loci that are involved in atopy. These findings highlight how epigenetic changes can have long-term immunomodulatory effects and exacerbate atopic diseases.