Bone Nano-ossification

Background. The bone regeneration capability is established on the premise that progenitor cells, either engaged or carried to a damaged site, can restore lost or injured tissue. Osteoblasts use trifold assembly to layer and synchronize Ca²⁺ and P0₄^3- deposition. Simultaneous progress and refinement of bionanotechnology, in combination with the rising of nanomedicine, yields engaging new approaches as the use of biomaterials that support synthetic methods to engage bone generation. Methods. We developed and studied a new peptide amphiphile (Osseous-OB2). The healing and remineralization potentials of this bioactive amphiphile (0.5%) were assessed using topical application in skull fractures in adult rat models (n=30). We established two study groups; the first treated with Osseous-OB2, the second was the control group. Depending on the situations, we would use one-way repeated-measures ANOVAs. Results. One week after the Osseous-OB2 application, we sacrificed the animals and detected the facture closure in all the participants (n=15) in the first group. While in the second group (n=15), 87% of the specimen died (p=0,001). Conclusion. This biomaterial is the initial step to the potential solution of osseous decalcification problems; we demonstrate that this peptide sequence could be used for management of osteoporosis, fracture closures and genetic bone abnormalities.