Virtual Liver: Towards Drug Discovery Using In Silico Biological Pathways

Friday, 14 February 2014
Grand Ballroom E (Hyatt Regency Chicago)
Vijay Chandru , Strand Life Sciences, Bengaluru, India
Virtual Liver has been developed with a deep understanding of the molecular mechanisms that underpin liver biology. We have incorporated several key pathways in the liver such as the antioxidant metabolism, energy metabolism, lipid and bile acid metabolism. As a result our model not only mimics normal liver function faithfully but also generates likely outcomes under a variety of perturbations including drug exposure. Our system has been validated with well-known hepatotoxic drugs.