Friday, 14 February 2014
Grand Ballroom A (Hyatt Regency Chicago)
The X-linked region known as the 'X-inactivation center' (Xic) was once dominated by protein-coding genes but, with the rise of Eutherian mammals some 150-200 million years ago, became infiltrated by genes that produce long noncoding RNA (lncRNA). Some of the noncoding genes have been shown to play crucial roles during X-chromosome inactivation (XCI), including the targeting of chromatin modifiers to the X. The rapid establishment of lncRNA hints at a possible preference for long transcripts in some aspects of epigenetic regulation. We will consider advantages lncRNA offers in delivering allelic, cis-limited, and locus-specific control. Examples include Xist, Tsix, and Jpx. The mechanisms by which they repress and activate gene expression will be discussed.