Recent changes proposed for the testing and admission process for medical school in the United States have focused attention on the structure of the premedical curriculum, particularly on the previously rigid course requirements in biology, chemistry, physics, and mathematics. The substitution of competencies for courses opens the door for creative interdisciplinary curriculum design and collaboration between disciplines. This interactive session will have brief presentations on several innovative courses and curriculum plans that integrate multiple disciplines. After the talks, the audience will break into small groups to discuss the challenges to implementing these curricula and brainstorm some possible solutions for overcoming resistance to change. The session will end with reports from the small groups and a summary by the facilitators.