Henry and Lucy Moses Professor of Science and University Professor, Center for Neurakl Science, New York University Dr. LeDoux has carried out pioneering and comprehensive studies of the neuroscience of fear learning and fear memory. In an animal model, he traced the fear processing circuit from sensory systems to the amygdala, identified the lateral nucleus of the amygdala as a key sensory region and a site for synaptic plasticity, and showed that the connections from the lateral to the central nucleus are essential for processing fear responses. He has also elucidated the phenomenon of extinction, related extinction to the medial prefrontal cortex, and shown how medial prefrontal cortex interacts with the amygdala in extinction. His work has substantial clinical relevance for the treatment of anxiety disorders.