Most science informed policy incorporates both scientific expertise as well as stakeholder and public input. However, only certain approaches attempt to combine perspectives across these groups to provide synthesized policy input, rather than leaving policy-makers to assess the diverse interests and positions. Recent research in public engagement related to science has led to innovations in Web-based models, deliberative engagement, stakeholder engagement, and community-based discussions. Models of governance for large-scale biological research platforms are emerging to incorporate explicitly transparent management of uncertainty and unintended consequences and structured representation and engagement of community members. While some methods are well suited for understanding local and jurisdictional public interests and perspectives, others offer a better chance of identifying components of international collaboration suitable for issues that are global in their reach. The purpose of this symposium is to offer an overview of a range of innovative approaches in the governance of science and technology. Assessments include cost-efficiency, lack of effect on policy, poor representation, uninformed policy input, and capture by stakeholders.