Remineralization of Human Enamel Using a Self-Assembling Bioactive Matrix

The remineralization capability of human enamel, the solidest tissue in the body, is essentially limited. Concurrent progress and sophistication of biotechnology in conjunction with the rising of nanomedicine yield appealing new prospective, like the use of biomaterials that promote synthetic approaches to support enamel formation that have the potential to repair loss, increase the durability of teeth. Here we developed and investigated a new peptide amphiphile (PA-DENT02). The healing and remineralization potentials of this bioactive amphiphile (0.5%) were assessed using topical application in children with demineralization problems (n=32; ages=6 -12 years) during four weeks. We establish two study groups; the first treated with PA-DENT02, the second with fluoride and the third was the control group. Three weeks after PA-DENT02 regimen, we detected ectopic formation of enamel in all participants (n=14), while in the second group (n=14) the remineralization was observed after three months (p=0,001). This is the first time that this biomaterial has been used in demineralization troubles and we report that this triggered formation of structured mineral validate a pathway for developing biomaterials for treatment of dental caries, the most common disease in man.