Ultimately, science and technology (S&T) in international development and diplomacy must do more than create new researchers and build institutions -- it must build bridges to other institutions, to governments, and to the business community to solve developing country challenges and boost economic growth. All of the major challenges in development, even democracy and conflict, have some foundation in S&T in terms of identifying the threats or providing the solutions. Some challenges, such as climate change and access to clean energy, must be addressed by both developed and developing nations. Others, such as building food security, addressing global health challenges, and building knowledge-based economies will require a different focus for developing countries. This session will highlight existing and proposed mechanisms, partnerships, and programs in the developing world that have built research and institutional capacity, expanded S&T expertise beyond academia into broader economic growth and use, and highlighted innovative ways to use S&T to solve development challenges.