The integrity of science is grounded in generally accepted standards for the conduct of scientific inquiry. In practical terms, however, there are national differences in how integrity standards are defined, interpreted, and met. Practices that are acceptable in one country may not be acceptable in a different national context. As cross-national collaborations expand, scientists increasingly find their work subject to variations in regulations, enforcement, and norms of practice. As a result, compromises to research integrity can be more difficult to anticipate and correct internationally. These issues are being addressed on several fronts, as represented in this symposium: the 2010 Second World Conference on Research Integrity in Singapore; the initiatives launched jointly by AAAS and the China Association for Science and Technology (CAST) through the AAAS-CAST Steering Committee on Ethics in Science; and the integrity-related initiatives of the International Council for Science (ICSU). Panelists will also report on empirical analyses of national integrity efforts across Asia and integrity issues in international research collaborations.