The interest in personalized medicine is growing and basic; applied and translational research is advancing to make available to the public tools and technology that enable them to be their primary care provider by being able to monitor wellness, metabolic activity, and the signs of illness onset through the use of both biofunctioning diagnostics and devices. There is concern being expressed that there is a lack of research being performed on sample integrity and reference material for sound experimental controls. If one examines the fast pace of biotechnology over the past three decades, there has been a lack of emphasis on setting and establishing biostandards in most of the "omics" being used in today’s medical research arena. This symposium will bring together various researchers in biomedicine that can address the needs and gaps within genetic profiling and genomics as well the lack of studies focused on how biological samples are collected and stored as well as recommendations to move forward in addressing what is viewed as a serious problem in making personalized medicine a stable and reproducible science.