Theodore Maiman demonstrated the first device capable of light amplification by stimulated emission of radiation approximately 50 years ago. Lasers have found many uses in clinical medicine since that time because of their ability to direct high-energy radiation of a single wavelength onto a focused location. Current medical applications involve use of the laser as an “optical scalpel” in minimally invasive techniques that involve little blood loss, little or no laser-tissue contact, and accurate removal of unwanted tissue. Lasers are also finding greater use in processing biomaterials, which are used to replace missing or damaged tissues. Several laser-based methods, including selective laser sintering/melting, laser machining, matrix-assisted pulsed-laser evaporation direct write, stereolithography, and two-photon polymerization, have been used for processing biomaterials with microscale and sub-microscale features. These methods have been used to process a variety of biomaterials, including cardiac stents, patient-specific prostheses, medical sensors, drug delivery devices, and scaffolds for regenerative medicine. This symposium will bring together clinicians, engineers, biological scientists, computer scientists, and physical scientists for a discussion of current developments in this exciting interdisciplinary area.