A California Roadmap for Identifying Chemicals that Affect Breast Cancer Risk

Friday, February 19, 2010: 1:30 PM-3:00 PM
Room 6D (San Diego Convention Center)
People are exposed to a myriad of chemicals in their daily life. Modest toxicity information exists for only some of these chemicals, including their ability to alter breast development and disease risk. Yet, breast cancer remains one of the leading causes of death among women. In animal models, early life exposures to low doses of chemicals, particularly endocrine disrupting substances, increase the risk for breast cancer by affecting mammary development and lifetime susceptibility to cancer. Chemical regulations currently under development as part of Californiaís Green Chemistry Initiative will require new decision-making tools for identifying and prioritizing chemical hazards. Over the past year, an expert panel convened by the University of California, Berkeley has examined the biological pathways governing breast carcinogenesis and the toxicity tests that can improve scientistís ability to detect chemicals likely to affect breast development and carcinogenesis. The panel recommends improvements to chemical toxicity screens to increase their relevance for human breast cancer. Panel recommendations are based on currently available toxicity tests and biomolecular and pathology studies. They define a testing scheme for identifying chemicals that may affect breast development and cancer susceptibility, reproductive harm, and other cancers. Identifying such environmental factors will inform effective regulation of chemical hazards and improve breast cancer prevention efforts.
Sarah Janssen, Natural Resources Defense Council (NRDC)
Gabriela Chavarria, NRDC
Megan Schwarzman, University of California
Using Existing Science and Toxicology in Chemicals Policy
Suzanne E. Fenton, National Institute of Environmental Health Sciences (NIEHS)
Early Life Exposures: Lifelong Impact on Mammary Gland Development and Function
Lauren Zeise, California Environmental Protection Agency
Identifying Potential Breast Carcinogens