On February 25, 1985, the National Science Foundation (NSF) launched a new partnership with four of the nation’s leading universities to invest in the creation of supercomputer centers to help solve some of the nation’s most pressing “grand challenges.” The NSF supercomputer center program was established as a critical cornerstone to promote discovery, harness innovation, push our knowledge, and help the next generation fulfill its promise. The centers were designed to help U.S. researchers retain their global lead in scientific computation, acquired after World War II through federal investments. They also were meant to broaden access to advanced computing facilities for researchers unable to tap into supercomputer networks under the aegis of other federal agencies. To commemorate the 25th anniversary of this national research initiative and to forecast key research and technological goals over the next quarter century, this symposium will explore how computational science, and its enabling cyberinfrastructure, is tackling some of the “grand challenges” facing science and society today and explore growth in the future as science undergoes a fundamental shift to a computer- and data-dominated enterprise. Each presenter will highlight a historical breakthrough made possible by computational science in the last 25 years and discuss how cyberinfrastructure-enabled research is bridging scientific problems to societal challenges in the next quarter-century.