This symposium shares lessons being learned about research translation by a binational team of scientists, educators, multimedia experts, government partners, and community-based organizations. The team’s effort focuses on the water, climate, and poverty nexus and transboundary environmental risk along the U.S.-Mexico border. The team’s partnership-driven approach seeks solutions to complex problems. Many cutting-edge scientific, socio-technical, and cultural challenges are raised in the process. These challenges serve as the symposium’s organizing framework -- as conveyed in a 28-minute University of California, San Diego, documentary that will be shown before the presentations to help set the stage for discussion. The documentary features the team’s effort to integrate environmental health science (including ecotoxicology and biomolecular technologies) with climate-change science and regional watershed-based planning. The bulk of the funding for this work comes from the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program. The program supports holistic approaches to research, including research translation and outreach, for the protection of human health. This is accomplished through interdisciplinary programs that integrate biomedical research with engineering, hydrogeologic, and ecologic components within the context of unique scientific themes.