Scientific evidence linking oral health to general health continues to accumulate. Oral diseases and disorders affect an individual's health and well-being throughout life. But despite many improvements in oral health, significant disparities in oral disease (dental caries) experience remain, with the poor, the young, and elderly shouldering the greatest burden. This program will explore the many facets of oral health disparities in vulnerable populations to better understand and implement the most apposite strategies necessary for their reduction. A global perspective of disease prevalence will be presented with a discussion of community approaches to reducing disease experience. The biological and behavioral approaches to disease prevention will also be discussed in light of our current scientific knowledge. Finally, current and future development of health policies that address the costs and modes of care delivery will be discussed.