Centered on this vision, in this talk I will introduce fundamentally new imaging and detection architectures that can compensate in the digital domain for the lack of complexity of optical components by use of novel theories and numerical algorithms to address the immediate needs and requirements of Telemedicine for Global Health Problems. Specifically, I will present an on-chip cytometry and microscopy platform that utilizes cost-effective and compact components to enable digital recognition and 3D microscopic imaging of cells with sub-cellular resolution over a large field of view without the need for any lenses, bulky optical components or coherent sources such as lasers. Applications of this lensfree on-chip microscopy platform to high-throughput imaging and automated counting of whole blood cells, monitoring of HIV+ patients (through CD4 and CD8 T cell counting) and detection of waterborne parasites towards rapid screening of water quality will also be demonstrated. Finally, I will demonstrate lensfree on-chip imaging of fluorescently labeled cells over an ultra wide field of view of >8 cm2, which could be especially important for rare cell analysis (e.g., detection of circulating tumor cells), as well as for high-throughput screening of DNA/protein micro-arrays.
See more of: Development
See more of: Symposia