Emerging zoonotic diseases, food- and water-borne diseases, and environmental change pose increasing threats to health on a global basis. Improvements are needed in our ability to detect and respond to emerging zoonotic agents, particularly those that appear suddenly and are capable of spreading over large areas. The emergence of diseases is a huge public health threat everywhere, especially with the impact of being able to travel to any point in the world in a day. Diseases do not respect borders. This session will focus on implementing One Health principles through concrete actions, in particular, via monitoring and surveillance at the human-animal-environment interface.