One Health is a concept that addresses contemporary health issues created by the convergence of human, animal, and environmental domains. The health of each domain is inextricably interconnected, yet practices in human and veterinary medicine and environmental issues often do not recognize these links. The panel will address these interconnections and interdependencies, noting how environmental degradation creates favorable settings for the expansion of infectious and other diseases and that the majority of diseases now recognized in humans are multihost pathogens that cross species lines. An increasing interdependence with animals and their products is a critical risk factor to our own health and well-being with regard to infectious diseases. Achieving optimal health for people, animals, and the environment through an integrated, holistic strategy is one of the critical challenges facing us today.